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腾讯登录安德森癌症研究中心获NIH资助胰腺癌生物标志物研究
| 导读 | 近日，美国国立卫生研究院(NIH)给予美国安德森癌症中心一个研究小组(MD Anderson Cancer Center)一年的研究资助用于跟进前期的研究结果，在NIH的资助下，美国安德森癌症中心的研究人员将利用特定的microRNAs分子作为生物标志物来鉴别可以进展为入侵性肿瘤的高风险胰腺肿瘤。 |
近日，美国国立卫生研究院(NIH)给予美国安德森癌症中心一个研究小组(MD Anderson Cancer Center)一年的研究资助用于跟进前期的研究结果，在NIH的资助下，美国安德森癌症中心的研究人员将利用特定的microRNAs分子作为生物标志物来鉴别可以进展为入侵性肿瘤的高风险胰腺肿瘤。
胰腺导管内乳头状黏液性肿瘤(Intraductal papillary mucinous neoplasms， IPMNs)是一种频繁但不总是发生的囊性病变，其通常会发展成为胰腺导管腺癌(pancreatic ductal adenocarcinoma)。研究人员的大量工作就是鉴别出特殊的生物标志物，来将可以发展成为胰腺导管腺癌的高风险IPMNs)同低风险的无痛性胰腺囊肿进行区分；早在2014年研究人员就报告表示，他们已经可以利用新一代的测序技术对来自良性和侵入性的胰腺囊性病变的囊肿液中的miRNAs进行特性描述，从而就可以发现一系列在入侵性囊肿液中被正向或负向调节的miRNAs分子。
如今研究人员Sen及其同事获得了NIH 20多万美元的资助用于进行IPMN患者机体中miRNAs更广泛的新一代测序分析，进而帮助建立可以利用测序和RT-PCR技术区分不同病人机体miRNA特性的新研究；下一步研究人员计划寻找在囊肿液和血浆中潜在的胰腺癌miRNAs生物标志物重叠标志物。（转化医学网360zhyx.com）
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MD Anderson Team Wins NIH Grant for Pancreatic Cancer Biomarker Study
The National Institutes of Health has awarded an MD Anderson Cancer Center team a one-year grant to follow up on preliminary data suggesting that certain microRNAs can be used as biomarkers to identify pancreatic neoplasms at high risk for progressing into invasive tumors.
Intraductal papillary mucinous neoplasms, or IPMNs, are cystic lesions that frequently, but not always, progress into pancreatic ductal adenocarcinoma (PDAC).
As part of an effort to identify biomarkers that can be used to stratify IPMNs at high risk for progressing into PDAC from low-risk indolent pancreatic cysts, MD Anderson's Subrata Sen and colleagues in 2014 reported on the use of next-generation sequencing to profile miRNAs in cyst fluid from benign and invasive pancreatic cystic lesions, which revealed a number of miRNAs that were either up- or downregulated in invasive cyst fluid.
To build on these findings, Sen and his team have now received $223,369 from the NIH to conduct broader NGS analyses of miRNAs within cyst fluid from IPMN patients with low-grade dysplasia and those with high-grade invasive cancer in order to establish an miRNA signature that can differentiate the two patient populations using both sequencing and RT-PCR.
The researchers also plan to look for overlap between potential pancreatic cancer miRNA biomarkers in cyst fluid and in plasma, according to the grant's abstract.
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