推荐活动

科学家阐明引发男性不育症的根本原因

首页 » 研究 » 检验 2015-06-19 转化医学网 赞(2)
分享: 
导读
卡罗琳学院的研究者最新研究发现,男性不育或许和自身免疫性前列腺炎症直接相关,该研究刊登于国际杂志Science Translational Medicine上。非自愿不生育是常见的,而且在所有不育的男性中占到了一半,尽管男性不育存在很多原因,但目前研究者并无定论。

  卡罗琳学院的研究者最新研究发现,男性不育或许和自身免疫性前列腺炎症直接相关,该研究刊登于国际杂志Science Translational Medicine上。非自愿不生育是常见的,而且在所有不育的男性中占到了一半,尽管男性不育存在很多原因,但目前研究者并无定论。
  当前研究中,研究者发现了引发自体免疫多内分泌症1型(APS1)患者生育力下降的原因,而生育力的下降会增加个体患自身免疫疾病的风险,因此APS1个体通常会被用作研究自身免疫疾病的模型。
  不孕不育是一种常见的两性疾病,APS1女性患者不孕是因为其自身的免疫活动抑制了机体卵巢的功能而致,而引发男性不育的原因至今并不清楚;文章中研究者调查是否男性的不育是因为自身免疫反应抑制了男性生殖器官的功能而致,随后研究者对患APS1的93名男性和女性个体进行了研究,调查了其机体的免疫系统的功能。
  研究者Nils Landegren教授说道,我们发现,一大群病人的机体免疫系统会对前列腺中产生的一种蛋白产生反应,这种蛋白名为谷氨酰胺转移酶4,而且研究者发现仅仅对谷氨酰胺转移酶4产生反应的男性机体会发生不育,更有意思的是,此前对小鼠的研究表明谷氨酰胺转移酶4在雄性不育中扮演着重要作用。
  为了理解上述研究发现,随后研究者对APS1动物模型进行了研究,结果发现雄性小鼠会自发地在其前列腺组织中产生一种炎性疾病,即前列腺炎,同时动物模型机体还会对谷氨酰胺转移酶4产生反应;本文研究为阐明男性不育的原因提供了新的思路,但后期还需要进行更多的研究来理解自身免疫性前列腺炎如何引发男性不育,从而就会后期开发有效治疗男性不育的新型靶向疗法提供了新的希望和帮助。(转化医学网360zhyx.com)
  以上为转化医学网原创翻译整理,转载请注明出处和链接!
转化医学网推荐的原文摘要:

Transglutaminase 4 as a prostate autoantigen in male subfertility
Science Translational Medicine 
 N. Landegren, D. Sharon, A. K. Shum, I. S. Khan, K. J. Fasano, Å. Hallgren, C. Kampf, E. Freyhult, B. Ardesjö-Lundgren, M. Alimohammadi, S. Rathsman, J. F. Ludvigsson, D. Lundh, R. Motrich, V. Rivero, L. Fong, A. Giwercman, J. Gustafsson, J. Perheentupa, E. S. Husebye, M. S. Anderson, M. Snyder, O. Kämpe
Infertility is common in people of both sexes with the disease. While infertility in women with APS1 is caused by autoimmune action against the ovaries, what gives rise to the corresponding infertility in men has never been ascertained. Keen to investigate whether male fertility could be explained by an autoimmune reaction against some part of the male reproductive organs, the researchers behind this new study examined the immune system of 93 men and women with APS1.
"We found that the immune system in a large group of patients reacted to a protein formed only in the prostate, namely the enzyme transglutaminase 4," says lead investigator Dr Nils Landegren at Karolinska Institutet's Department of Medicine in Solna. "What we found was that it was only men who reacted to transglutaminase 4 and that the immune reaction first appeared at the onset of puberty once the prostate gland had matured. Interestingly, previous studies on mice have shown that transglutaminase 4 plays an important part in male fertility."
To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands - a so-called prostatitis - and reacted to transglutaminase 4.

评论:
评 论
共有 0 条评论

    还没有人评论,赶快抢个沙发

相关阅读